Jarrow Formulas GPLC, Supports Arterial Blood Flow, 750 mg, 60 Tabs

The effects of GPLC extend beyond that of mere L-carnitine. In fact,propionyl-L-carnitine (PLC), a patented propionyl ester of L-carnitine, has undergone many clinical studies. PLC has been documented to increase the oxidation of both glucose and lactate, increase exercise capacity, and increase both mental and overall energy.* PLC also appears to improve muscle glycogen stores while increasing the time to develop muscular fatigue.* And PLC used in conjunction with CoQ10 seems particularly beneficial for heart health.* Compared with at least one other form of L-carnitine, PLC appears to produce greater increases in cellular L-carnitine concentrations. Researchers believe that PLC is transported more easily into muscle tissues and supports energy production, perhaps because it increases the flow of pyruvate into the Krebs cycle.* The Krebs cycle is a major component in the body’s energy pathways. Various intermediate products of the Krebs cycle have special roles in physiology and energy production. Supplemental L-carnitine taps into this pathway and is associated with significantly higher concentrations of pyruvate, ATP and creatine phosphate (crucial components in energy production) in portions of the heart muscle during conditions of extreme stress.*

Nitric Oxide (NO) is a messenger utilized by the body to signal the smooth muscle surrounding blood vessels to relax, allowing the vessels to widen and causing increased blood flow. Exercise enthusiasts make attempts to bolster NO effects like improved blood-flow, increased muscle endurance and more efficient post-workout recovery by supplementing with biochemical precursors of NO, like L-arginine. GPLC research suggests that its effects on NO production in the body may be how it mediates its cardiovascular and sports nutrition effects.* Recent studies conducted by Dr. Bloomer at the University of Memphis have found that a daily oral dosage of 4.5 grams of GPLC increases blood levels of NOx. NOx is a measure of nitric oxide metabolites in the blood.* In one double-blind study, men and women who were not previously exercise-trained were randomly assigned to take either placebo or GPLC in conjunction with aerobic exercise for eight weeks. The group administered 4.5 grams/day of GPLC had a statistically significant increase in blood-levels of NOx. This study gives evidence to support a GPLC induced increase in resting NO levels.* In a second double-blind study, the effects of 4.5 grams/day GPLC versus placebo were evaluated in resistance-trained men. After four weeks of placebo or GPLC use, blood levels of NOx were measured following forearm exercise. The GPLC group showed significant increases in NOx levels at three and ten minutes post protocol. This study may indicate enhanced blood flow due to a GPLC induced increase in active NO levels.*