L-Citrulline is an amino acid with the main benefits of muscle growth, sustained muscle protein synthesis, and post-training recovery. All of these benefits are attributed to elevated blood arginine levels which have lead to greater Nitric Oxide (NO) production, muscle protein synthesis, and faster recovery. The process in which Citrulline is effective for reducing fatigue during training comes from the exchange typically produced. Citrulline is produced when Ornithine combines with Carbamoyl Phosphate, which occurs during the urea cycle when your body removes nitrogen waste. The addition of supplementing Citrulline in the body is said to put the urea cycle in overdrive, allowing it to suck up more ammonia (composed of nitrogen molecules) which are produced by working muscles. This in combination reduces the fatigue caused by muscles at the source. The excess of Citrulline triggers a stronger effect of arginine conversion into nitric oxide (NO). The increase in arginine in the blood leads to increased NO production, the increase of NO increases blood flow during exercise and allows for muscles to perform for longer while under duress, which gives weightlifters the ability to produce bigger muscle pumps.
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